Randox Toxicology provides highly sensitive ELISA kits for the rapid detection of drugs and metabolites in various biological specimens. Offering the highest quality ELISAs available on the market, our results provide excellent correlation with confirmatory methods. Through significant re-investment in Research and Development, Randox Toxicology introduce an exclusive ELISA kit for MT-45.
MT-45 (IC-6) is an opioid analgesic drug, chemically 1-substituted-4 (1, 2-diphenylethyl) piperazine derivative and structurally unrelated to most other opioid drugs. Racemic MT-45 has around 80% the potency of morphine, with almost all opioid activity residing in the (S) enantiomer (the opposite stereochemistry from the related drug lefetamine).
Developed by Dainippon Pharmaceutical CO., a Japanese pharmaceutical company in the 1970s, MT-45 became popular in 2013 through online vendors. Described as similar to codeine or methadone, the effects of the drug include itching, nausea, vision impairment, and insomnia. Common users of the drug have been males aged 16 – 40 (particularly 20 – 35), with oral administration proving the most popular method of consumption. MT-45 has caused a number of deaths used by itself and combined with other substances such as, etizolam, ethanol, pyrazolam, and flubrazolam. Reports state that the drug is associated with hearing loss and unconsciousness, with documented deaths and overdoses producing comas, respiratory depression, tachycardia, drowsiness, and hypoxia and cyanosis.
MT-45 is banned in the Czech Republic and became a Class A drug in the UK on 11th March 2015. The Canadian Controlled Drugs and Substances Act was amended in 2016 to include the substance as a Schedule I substance. Possession without legal authority can result in a maximum of 7 years imprisonment. Further, Health Canada amended the Food and Drug Regulations in May 2016, to classify MT-45 as a restricted drug. Only those with a law enforcement agency, person with an exemption permit or institutions with Minister’s authorisation may possess MT-45 in Canada.
Due to pressure to control the production of synthetic opioids, Chinese factories are to ban four NPS drugs, including MT-45 and U-47700 from the 1st July 2017. Justin Schoeman, from the US Drug Enforcement Administration stated that when China controls a substance, it has a huge impact on seizures and availability in America. However, MT-45 is currently not illegal in the US.
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