Pregabalin

Pregabalin was invented by Richard Bruce Silverman in the United States of America to replace Gabapentin. Pregabalin is used for the treatment of neuropathic pain, partial seizures and generalized anxiety disorders. It is also used to treat fibromyalgia in the USA and is listed as one of the top 30 prescribed medications. Pregabalin is eliminated from the systemic circulation primarily by renal excretion as unchanged drug with a mean half-life of 6.3 hours in subjects with normal renal function. The side effects of pregabalin can include asthenia, dry mouth, constipation, peripheral edema, dizziness, somnolence, confusion and blurred vision. Serious side effects include sedation, respiratory failure and death.

Product Number: PGB10082

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Cross Reactivity

AnalyteLODMatricesCompoundsCross Reactivity %
Pregabalin0.159 µg/mLWhole Blood, Post Mortem Blood, UrinePregabalin100
DMAA2.2
Gabapentin<1
Felbamate<1
Retigabine<1
Lacosamide<1
Stiripentol<1
Acetylcholine CI<1
D-Glutamic Acid<1
L-Glutamic Acid<1
Tiagabine HCI<1
Gamma-Aminobutyric Acid<1
N-methylpregabalin<1
Valporic Acid<1
Levetiracetam<1
Topiramate<1
Serotonin<1
Carbamazepine<1
Vigabatrin<1
Phenobarbital<1
*LOD is standardised to this compound