TCAs (Tricyclic Antidepressants)

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Tricyclic antidepressants (TCAs) are a group of drugs that contain a characteristic three ringed nucleus structure. TCAs work by inhibiting the reuptake of serotonin and norepinephrine back into brain cells and are rapidly absorbed and have a long half-life. TCAs drugs include Amitriptyline, Amoxapine, Desipramine, Doxepin, Imipramine, Nortriptyline, Proptriptyline and Trimipramine. They have been used in the treatment of various forms of depression, anxiety disorders, attention deficit hyperactivity disorder and enuresis in children. TCA antidepressant drugs are among the most toxic and commonly encountered causes of self-poisoning compared to other types of antidepressants.

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Cross Reactivity

Analyte	Compound	Cross Reactivity % CR%
TCAs (Tricyclic Antidepressants) LOD: 10.9 ng/mL	Nortriptyline	100
	Imipramine N-oxide	1127
	N-desmethyl Trimipramine	396.5
	Imipramine	294
	Trimipramine	238
	Desipramine	206
	Cyclobenzaprine	201
	Amitriptyline	190
	Opipramol	167
	Promazine	117
	Maprotiline	96
	Doxepine	95
	Clomipramine	76
	Protriptyline	67
	Northiaden (Nordothiepin)	63.2
	Cyproheptadine	61
	Lofepramine	58
	Dothiepin	50
	Chlorpromazine	24.3
	Norclomipramine HCI	22.1
	2-Hydroxy imipramine	19.5
	Nordoxepin	19.4
	Perphenazine	17.3
	Prochlorperazine	9.3
	10-OH amitriptyline	6.4
	2-OH desipramine	5.1
	Quetiapine Fumarate	4.5
	Thioridazine HCI	0.5
	Carbamazepine	0.3
	Cetirizine diHCI	0.3
	Orphenadrine HCI	0.2
	Amoxapine	0.1
	Hydroxyzine diHCI	<0.1
	Oxcarbazepine	<0.1
	Diphenhydramine HCI	<0.1
	Carbam,azepine 10,11 epoxide	<0.1
	10-Hydroxynortriptyline	<0.1
	Iminostilbene	<0.1
	Mianserin	<0.1
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