TCAs (Tricyclic Antidepressants)

Tricyclic antidepressants (TCAs) are a group of drugs that contain a characteristic three ringed nucleus structure. TCAs work by inhibiting the reuptake of serotonin and norepinephrine back into brain cells and are rapidly absorbed and have a long half-life. TCAs drugs include Amitriptyline, Amoxapine, Desipramine, Doxepin, Imipramine, Nortriptyline, Proptriptyline and Trimipramine. They have been used in the treatment of various forms of depression, anxiety disorders, attention deficit hyperactivity disorder and enuresis in children. TCA antidepressant drugs are among the most toxic and commonly encountered causes of self-poisoning compared to other types of antidepressants.

Whole Blood
Post Mortem Blood
Oral Fluid
Vitreous Humor

Cross Reactivity

Analyte Compound
Cross Reactivity %
TCAs (Tricyclic Antidepressants)
LOD: 10.9 ng/mL
Nortriptyline 100
Imipramine N-oxide
N-desmethyl Trimipramine

All data in the above table refers to our whole blood matrix.

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