Tramadol is a synthetic opioid-receptor agonist that has been used clinically as a narcotic analgesic since 1977. Tramadol also inhibits the reuptake of monoamines such as norepinephrine and serotonin, which enhances its analgesic effect. O-desmethyltramadol has 2-4 times the analgesic efficacy of the parent drug. In all body tissues and blood, the drug concentration is greater than the N-desmethyl and O-desmethyltramadol metabolites, and O-desmethyltramadol is always greater in concentration than the N-desmethyl metabolite. There are numerous reports of tramadol toxicity and abuse. Overdoses of ≥500 mg may cause agitation, hypertension, tachycardia and seizures, while doses >800 mg may cause coma and respiratory depression.
Product Number: TRM3499
Analyte | LOD | Matrices | Compounds | Cross Reactivity % |
---|---|---|---|---|
Tramadol | 0.86 ng/mL | Whole Blood, Post Mortem Blood, Urine | Tramadol | 100 |
O-desmethyltramadol (Hydroxytramadol) | 57 | |||
N-desmethyltramadol (Nortramadol) | 4 | |||
rac N,O-didesmethyltramadol (Norhydroxytramadol) | 1 | |||
Phencyclidine (PCP) | <0.1 |