Tramadol is a synthetic opioid-receptor agonist that has been used clinically as a narcotic analgesic since 1977. Tramadol also inhibits the reuptake of monoamines such as norepinephrine and serotonin, which enhances its analgesic effect. O-desmethyltramadol has 2-4 times the analgesic efficacy of the parent drug. In all body tissues and blood, the drug concentration is greater than the N-desmethyl and O-desmethyltramadol metabolites, and O-desmethyltramadol is always greater in concentration than the N-desmethyl metabolite. There are numerous reports of tramadol toxicity and abuse. Overdoses of ≥500 mg may cause agitation, hypertension, tachycardia and seizures, while doses >800 mg may cause coma and respiratory depression.

Product Number: TRM3499

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AnalyteLODMatricesCompoundsCross Reactivity %
Tramadol0.86 ng/mLWhole Blood, Post Mortem Blood, UrineTramadol100
O-desmethyltramadol (Hydroxytramadol)57
N-desmethyltramadol (Nortramadol)4
rac N,O-didesmethyltramadol (Norhydroxytramadol)1
Phencyclidine (PCP)<0.1
*LOD is standardised to this compound