Tricyclic Antidepressants (TCA)

Tricyclic antidepressants (TCAs) are a group of drugs that contain a characteristic three ringed nucleus structure. TCAs work by inhibiting the reuptake of serotonin and norepinephrine back into brain cells and are rapidly absorbed and have a long half-life. TCAs drugs include Amitriptyline, Amoxapine, Desipramine, Doxepin, Imipramine, Nortriptyline, Proptriptyline and Trimipramine. They have been used in the treatment of various forms of depression, anxiety disorders, attention deficit hyperactivity disorder and enuresis in children. TCA antidepressant drugs are among the most toxic and commonly encountered causes of self-poisoning compared to other types of antidepressants.

Product Number: TCA10016

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AnalyteLODMatricesCompoundsCross Reactivity %
TCAs (Tricyclic Antidepressants)10.9 ng/mLWhole Blood, Post Mortem Blood, UrineNortriptyline100
Imipramine N-oxide1127
N-desmethyl Trimipramine396.5
Imipramine294
Trimipramine238
Desipramine206
Cyclobenzaprine201
Amitriptyline190
Opipramol167
Promazine117
Maprotiline96
Clomipramine76
Protriptyline67
Northiaden (Nordothiepin)63.2
Cyproheptadine61
Lofepramine58
Dothiepin50
Chlorpromazine24.3
Norclomipramine HCI22.1
2-Hydroxy imipramine19.5
Nordoxepin19.4
Perphenazine17.3
Prochlorperazine9.3
10-OH amitriptyline6.4
2-OH desipramine5.1
Quetiapine Fumarate4.5
Thioridazine HCI0.5
Carbamazepine0.3
Cetirizine diHCI0.3
Orphenadrine HCI0.2
Amoxapine0.1
Hydroxyzine diHCI<0.1
Oxcarbazepine<0.1
Diphenhydramine HCI<0.1
Carbam,azepine 10,11 epoxide<0.1
10-Hydroxynortriptyline<0.1
Iminostilbene<0.1
Mianserin<0.1
*LOD is standardised to this compound